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And protein kinase C (PKC) phosphorylation sites and a nuclear receptor-interaction box (NR, LXXLL) are underlined, and a nuclear localization sequence (NLS) in REA is boxed. With liver disease as they are unable to convert prednisone into an active substance. Not be used without the guidance of medical professionals so that side effects and complications can be caught, monitored, and controlled before they become too serious.
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